Understanding Statins: Your Guide to Cholesterol Management

What are Statins?

Statins are a class of medications commonly prescribed to help manage and lower cholesterol levels in the blood. They are particularly effective in reducing low-density lipoprotein (LDL) cholesterol, often referred to as "bad cholesterol." Elevated levels of LDL cholesterol can increase the risk of heart disease, heart attacks, and strokes. Statins work by inhibiting an enzyme in the liver that plays a key role in cholesterol production, leading to a decrease in LDL cholesterol levels. They have been use for nearly 30 years.


Who Should Take Statins?

Statins are typically prescribed to individuals who have been diagnosed with high cholesterol or those at high risk of developing heart disease. Your doctor will assess your cholesterol levels, medical history, lifestyle factors, and calculate an overall cardiovascular risk before deciding if statins are right for you. That risk is known as QRisk . NICE ( National institute of clinical Excellence) recommends that all patients with a Qrisk of greater than 10% should be offered a Statin. A Qrisk of 10% means that there is a 1in 10 probability of developing heart disease or Stroke over the following 10 years.

Patients who have chronic kidney disease with impaired kidney function would also benefit from taking statins.

Statins may also be recommended for those who have already experienced a heart attack or stroke to prevent further cardiovascular events.


Benefits of Statins:

  1. Reduced Risk of Cardiovascular Events: Statins have been shown to lower LDL cholesterol levels, reducing the risk of heart attacks and strokes, and helping to prevent cardiovascular events. Large scale studies have shown that the risk of death, heart attacks and strokes are reduced by approximately a third in patient taking statins.
  2. Anti-Inflammatory Effects: Statins may have additional benefits beyond cholesterol reduction. They possess anti-inflammatory properties that may protect blood vessels and improve overall cardiovascular health.
  3. Stabilizing Plaques: Statins can help stabilize atherosclerotic plaques in blood vessels, making them less likely to rupture and cause blockages.

How to Take Statins:

  1. Follow Doctor's Instructions: Take statins exactly as prescribed by your healthcare provider. The dosage and frequency will be determined based on your individual needs and response to the medication.
  2. Timing Matters: Statins are often taken at bedtime because the liver produces more cholesterol during the night. However, your doctor may advise a different dosing schedule.
  3. Consistency is Key: Try to take statins at the same time each day to maintain steady levels of the medication in your system.
  4. Food and Alcohol: Statins can be taken with or without food. However, excessive alcohol consumption should be avoided, as it may increase the risk of liver complications.

Potential Side Effects:

While statins are generally well-tolerated, some individuals may experience side effects. The risk of statins is often overstated in the media and the benefits vs harm ratio is hugely in favour of statins. Some common side effects include:

  1. Muscle Pain: Some people may experience muscle aches or weakness (2in 100 patients), although severe muscle-related issues are rare (3 in 10000).
  2. Diabetes: Approximately 1in 100 patients can develop diabetes due to taking statin.
  3. Digestive Issues: You may experience mild gastrointestinal symptoms such as nausea, diarrhoea, or constipation.

Precautions and Interactions:

  1. Inform Your Doctor: Always inform your doctor about any supplements and herbal products you are taking before starting statins. Certain medications or combinations may interact with statins and lead to adverse effects.
  2. Grapefruit and Grapefruit Juice: Avoid consuming large amounts of grapefruit or grapefruit juice, as it can interfere with the metabolism of statins and increase the risk of side effects.
  3. Pregnancy and Breastfeeding: Statins are generally not recommended during pregnancy or breastfeeding due to potential risks to the fetus or infant.

Alternatives to Statin:

If Statin is not tolerated or causes severe side effects then alternative medication can be prescribed. However these are less effective than statins in reducing heart disease and should only be given if a statin is not tolerated or contraindicated.



Statins can be an essential tool in managing cholesterol levels and reducing the risk of cardiovascular events. However, they are just one part of a comprehensive approach to heart health, which also includes a balanced diet, regular exercise, not smoking, and maintaining a healthy weight. Always consult your doctor for personalized advice, and never hesitate to address any concerns or side-effects you may experience during statin therapy.
For any questions or further information, consult your Practice or pharmacist.

This information is for educational purposes only and does not replace medical advice from a qualified healthcare professional.